BDNF Val66Met polymorphism and memory performance in older adults: the Met carrier effect is more complex than previously thought
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چکیده
منابع مشابه
BDNF Val66Met polymorphism and memory performance in older adults: the Met carrier effect is more complex than previously thought.
A, Sartori J, et al. Telomere length, oxidative stress, inflammation and BDNF levels in siblings of patients with bipolar disorder: implications for accelerated cellular aging. Int J Neuropsychopharmacol. 2017;20:445-54. 5 Czepielewski LS, Massuda R, Panizzutti B, da Rosa ED, de Lucena D, Macêdo D, et al. Telomere length in subjects with schizophrenia, their unaffected siblings and healthy cont...
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Objective: Memory impairment is an important contributor to the reduction in quality of life experienced by older adults, and genetic risk factors seem to contribute to variance in age-related cognitive decline. Brain-derived neurotrophic factor (BDNF) is an important nerve growth factor linked with development and neural plasticity. The Val66Met polymorphism in the BDNF gene has been associate...
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It has been suggested that the BDNF Val66Met polymorphism modulates episodic memory performance via effects on hippocampal neural circuitry. However, fMRI studies have yielded inconsistent results in this respect. Moreover, very few studies have examined the effect of met allele load on activation of memory circuitry. In the present study, we carried out a comprehensive analysis of the effects ...
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ژورنال
عنوان ژورنال: Revista Brasileira de Psiquiatria
سال: 2017
ISSN: 1516-4446
DOI: 10.1590/1516-4446-2017-2240